Classification types of skin cancer
There are three main types of skin cancer: basal-cell carcinoma (BCC), squamous-cell carcinoma (SCC) and malignant melanoma.
Cancer | Description | Illustration |
---|---|---|
Basal-cell carcinoma | Note the pearly translucency to fleshy color, tiny blood vessels on the surface, and sometime ulceration which can be characteristics. The key term is translucency. | |
Squamous-cell carcinoma | Commonly presents as a red, crusted, or scaly patch or bump. Often a very rapid growing tumor. | |
Malignant melanoma | The common appearance is an asymmetrical area, with an irregular border, color variation, and often greater than 6 mm diameter.[17] |
Basal-cell carcinomas are present on sun-exposed areas of the skin,
especially the face. They rarely metastasize and rarely cause death.
They are easily treated with surgery or radiation. Squamous-cell carcinomas
(SCC) are common, but much less common than basal-cell cancers. They
metastasize more frequently than BCCs. Even then, the metastasis rate is
quite low, with the exception of SCC of the lip, ear, and in people who
are immunosuppressed. Melanomas
are the least frequent of the 3 common skin cancers. They frequently
metastasize, and could potentially cause death once they spread.
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Less common skin cancers include: dermatofibrosarcoma protuberans, Merkel cell carcinoma, Kaposi's sarcoma, keratoacanthoma, spindle cell tumors, sebaceous carcinomas, microcystic adnexal carcinoma, Paget's disease of the breast, atypical fibroxanthoma, leiomyosarcoma, and angiosarcoma.
BCC and SCC often carry a UV-signature mutation indicating that these
cancers are caused by UVB radiation via direct DNA damage. However
malignant melanoma is predominantly caused by UVA radiation via indirect
DNA damage. The indirect DNA damage is caused by free radicals and
reactive oxygen species. Research indicates that the absorption of three
sunscreen ingredients into the skin, combined with a 60-minute exposure
to UV, leads to an increase of free radicals in the skin, if applied in too little quantities and too infrequently.
However, the researchers add that newer creams often do not contain
these specific compounds, and that the combination of other ingredients
tends to retain the compounds on the surface of the skin. They also add
the frequent re-application reduces the risk of radical formation.
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